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AGN 192870

CAS No. 166977-57-7

AGN 192870( —— )

Catalog No. M35574 CAS No. 166977-57-7

AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 148 In Stock
10MG 235 In Stock
25MG 454 In Stock
50MG 730 In Stock
100MG 1152 In Stock
500MG 2358 In Stock
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Biological Information

  • Product Name
    AGN 192870
  • Note
    Research use only, not for human use.
  • Brief Description
    AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
  • Description
    AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism. AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Retinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    166977-57-7
  • Formula Weight
    378.46
  • Molecular Formula
    C27H22O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.25 mg/mL (16.51 mM; Ultrasonic (<60°C)
  • SMILES
    CC1(C)C=2C(C(=CC1)C3=CC=CC=C3)=CC(C#CC4=CC=C(C(O)=O)C=C4)=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Klein ES, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem. 1996;271(37):22692-22696. ?
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